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DeCS
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Descriptor English:
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Protein Deglycase DJ-1
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Descriptor Spanish:
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Proteína Desglicasa DJ-1
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Descriptor Portuguese:
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Proteína Desglicase DJ-1
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Synonyms English:
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DJ 1 PARK7 Protein
DJ 1 Protein
DJ-1 Protein
DJ-1, Protein Deglycase
DJ-1-PARK7 Protein
DJ1 Protein
Deglycase, Parkinsonism Associated
PARK7 Protein
Parkinson Protein 7
Parkinsonism Associated Deglycase
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Tree Number:
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D08.811.277.785
D12.776.637.875
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Definition English:
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A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE. |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56493
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Unique Identifier:
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D000071617
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Occurrence in VHL:
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Similar:
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DeCS
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